Evaluation of the immunotropic activity of neuropeptide compound Lys-Lys-Arg-Arg-Pro-Gly-Pro in conditions of "social" stress

Objective: to investigate immunotropic activity of the argenine-containing neuropeptide compound Lys-Lys-Arg-Arg-Pro-Gly-Pro in conditions "social" stress. Material and methods. The study was conducted on mongrel male rats 6 months age using a model stress based provision permanent residence animals sensory contact, as result which submissive aggressive types behavior were formed. All divided into groups: control I - who cage one at time received water for injection an equivalent volume; II groups stressed with behavior; three intraperitoneally injected dose 100 mcg/kg/day comparison drug Imunofan (Arginyl-alpha-aspartyl-lysyl-valyl-thyrosyl-argininum) average therapeutic 0.7 mcg/kg/day. following indicators evaluated: delayed hypersensitivity reaction index, antibody titer direct hemagglutination reaction, phagocytic peripheral blood neutrophils, leukocyte formula indicators. Results. results obtained course this indicate that arginine-containing contributes correction immune changes occur against background exposure chronic stress, namely, increase level anti-erythrocyte antibodies, total number leukocytes decrease neutrophils (phagocytic index), well restoration percentage ratio elements formula. Conclusion. Thus, showed presence immunocorrecting effect cellular humoral links immunity, actualizes need detailed mechanisms compound.